Thursday, January 1, 2015
Endo-Cannabinoid Reuptake Inhibitors
Everyone in the world has Cannabinoids naturally in their brain, you actually have an entire "Endo-Cannabinoid System" which includes natural production of the Endocannabinoids called "2-AG" and "Anandamide", as well as the Cannabinoid Receptors known as CB1 and CB2.
An "Endo-Cannabinoid Reuptake Inhibitor" is a substance that has the ability to block the Reuptake of Cannabinoids. Let me explain for anyone who does not know what Reuptake is. For example, if you smoke a joint of Cannabis and the THC gets in your bloodstream, a certain amount makes it to the brain, then the rest stays in the bloodstream and sticks into fat cells and goes to be Urinated out. The THC that makes it to the brain then goes to the CB1 and CB2 receptors, and any THC that doesn't find a receptor gets "Reuptaken" and then put back in to the bloodstream to be urinated out. If you had a "Reuptake Inhibitor" then all the THC in the brain would have to find a spot before it was allowed to leave. This does not just work with THC, it also makes the natural 2-AG and Anandamide stay in your brain until it is used.
The most common example is Tylenol. Tylenol goes into the body and breaks down into AM-404, and AM-404 is an Endocannabinoid Reuptake Inhibitor.
Because of their action, Cannabinoids Reuptake Inhibitors could be used as Anti-Depressants in Professional Medical contexts. Normal Anti-Depressants are "Selective Serotonin Reuptake Inhibitors" there are "Endocannabinoid Reuptake Inhibitors". They have also shown the ability to fight Tumors and Cancer in Rats.
There are tons of these, and new ones being invented all the time. An example of one that can be purchased legally by anyone is LY-2183240.