Tuesday, December 30, 2014

Plants that act like Marijuana in the Brain, Basic Chemistry and Isomers

Caryophyllene,. It is a Marijuana Terpene used in the Perfume industry to give things a Marijuana smell, and recently I learned that it actually connects with the CB2 (Cannabinoid) receptor, even without any Cannabinoiids. So Caryophyllene has cannabis effects, even when taken outside or without Cannabis. Sources of Carryophyllene include Uziza Pepper 50% of Essential oil) and Indian Bay Leaves (25% of Essential Oil). So taking either of these things can and will increase the effects of the Cannabinoids.

Indole-3-Carbinol can be found in many common vegetables, and it breaks down to activate the CB2 receptor.

Common Rue Essential Oil activates the CB2 receptor.

Then I also learned more about Hash making. Remember when I said that you could use the Concrete making method and the Absolute making method from Dr. Atomic and the Perfume world? Well, there are steps you can take after that to ensure that your Cannabinoids are the BEST they can be.

First you do just like before. Using Lemonene or some other non-Polar solvent, make your Cannabis extract. Then add some kind of Alcohol (Ethanol, Isopropyl or Methanol) let that sit and eventually the Lemonene and Alcohol will separate. Use a Separatory funnel to separate these layers. St this point you have Cannabis absolute, aka medical grade hash in alcohol.

If you add a few drops of Sulfuric acid at this time, all the Cannabinoids will turn into THC Cannabinoids, and all the THC cannabinoids will become pure Delta-9-THC. That method was in the Dr. Atiomic book, I just did not add it before.

There are 2 other methods you can use at this point that I recently found out about.

When you have the medical grade hash, you can treat it with Acetic Acid instead of Sulfuric acid, and this will make THC-0-Acetate, which is a little bit stronger than THC.

or, You can extract the THC in Pyridine instead of alcohol, the add Phosphoryl Chloride, this will make THC-O-Phosphate which is weaker than THC, but can be used in hospitals easier, because it is water soluble which makes it injectable.

I will stop here now because I have made a wall of text, but I have been doing research for like 2 straight days with only like 8 hours of sleep total. So I can continue with this in a few days or weeks.

I decided not to wait a few days or weeks, I am going to continue the Chemistry stuff now.

When I was researching Nootropics a while ago I found what is called "Picamilon", this is a Nootropic which you can buy in America and they actually prescribe it to people in Russia. What it is is GABA powder and Niacin powder, these are both Amino Acids so they both have the properties of both an acid and a base depending on the situation. So during my research over the past few days, I decided to find out how Picamilon is made, and I found something out that may lead to some new Nootropics. Picamilon is just about the easiest Chemical reaction in the world. From what I learned, when you mix to Amino Acids together and apply heat, they will release H20 and form what is called a "Peptide Bond". So simply by putting GABA powder and Niacin powder in water (in equal amounts) and evaporating all the water away, you are creating "Picamilon". This substance has the ability to cross the blood brain barrier better than regular GABA, so it has a much stronger effect on those receptors. But it's not hard to make at all. So I am going to make some of that, and then maybe get some other Amino Acids and see what happens. Usually people wouldn't "invent" new molecules and eat them, but I am following in the footsteps of Sasha Shulgin. I will get some Amino Acids sometime in the next month or 2. Oilahuasca and Marijuasca come first.

I will continue this again later with Hydrogen Bonds and stuff.

I just want to say something that might help people understand this better. And I will help people understand even more when I get into the bonds. But if you want to understand Chemistry at its most BASIC, here is a good thought exercise.

First, accept that Chemical reactions are all just Magnets figuring out what they are attracted to. Chemistry is ALL ABOUT magnets, everything is polar or non-polar, acid or base, etc. and these things are basically all just magnetic responses that chemicals have to each other.

Now, understanding that it is all about Magnets, let's make it more clear with an example. Water. H2O. If you were to take 1 Hydrogen from H2O, suddenly it would be Hydroxide which is pretty much the STRONGEST most reactive base known to man. If you add a Hydroxide material (ex: Calcium Hydroxide) to water, the Hydrogen in the water becomes charged with a negative polarity and can be used to do things like extractions or pickling. Acids are the opposite of that. their Hydrogen is positively charged and is waiting connect to some other molecule. Acids usually have lots of Oxygen ready to attach magnetically to Hydrogen, Hydroxide or Hydrocarbons. If you add an acid to water, it charges the hydrogen in the water with a positive charge, and this can be used for extractions or as cleaning agents.

And when an acid and a base come together, they form a salt. Salts are usually neutral. And water is kind of like a salt, since it is Hydrogen and Oxygen in a higher concentration that in OH (Hydroxide). It is "acidic" hydrogen mixed with "basic" oxygen. It is not actually a salt, but noticing what it is made of can help you understand the magnet concept.

Ok, so as I mentioned before, THC can be treated with Acetic Acid in order to make THC-O-Acetate which is a little stronger by weight than THC itself. This can be done with other things as well. Most people have heard of Heroine and Morphine. Heroine is the Acetate form of Morphine, some people even make it by using vinegar which is about 5% acetic acid.

If you have heard of Choline, it improves brain function and promotes the creation of "AcetylCholine" in the brain, which is the specific thing that regulates dreaming. I am not positive, but I am pretty sure that AcetylCholine is the Acetic Acid treated form of Choline.

I am pretty sure that this process can be done with other things as well, like Catnip extract or possibly things like Kava which has similar effects to Marijuana.

Now, let's look at a THC Molecule.
http://en.wikipedia.org/wiki/Tetrahydrocannabinol#mediaviewer/File:Tetrahydrocannabinol.svg

On it are a bunch of Hydrocarbons, a Hydroxide and 2 Hydrogens. Meaning, any Oxygen, Fluorine or Nitrogen could alter it pretty completely. So I wonder if anyone has ever tried pickling their THC (adding Calcium Hydroxide aka Edible Lime to it). Or has anyone ever let Marijuana sit in a Hydrogen Peroxide solution, with maybe an Amino Acid? This could Change it completely also. Or letting it sit in some kind of Nitrogen solution. Morpholine is a Nitrogen and Oxygen, when someone adds morpholine to THC we are going to see some cool new medical applications, maybe.

Also, since Marijuana obviously forms Isomers with Acids (Sulfuric acid and Acetic acid), it might be worth testing other acids. I am pretty sure no one has ever treated THC with Tartaric acid, which is used in some medical applications. And I am almost positive it has never been treated with Malic acid, which is used in some foods and beverages, as well as occurring naturally.

THC could have all kinds of different forms that no one has even tried yet. And I am pretty sure no one has made any kind of 5-MeO-THC or anything like that yet, and from what I understand all it takes it some Methanol and something to activate the reaction in order to Methylate the THC into some X-MeO-form, unless I am mistaken.

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