Tuesday, December 30, 2014

How Oilahuasca Works


CYP Enzymes (Drug Metabolism, etc)
Induction and Inhibition (Anti-Oxidants, etc)


Cinnamon Bark- CYP2A6 & CYP2E1 Inhibitor (It will deplete your liver's Glutithione) Taken 1 Hour before Allybenzene,

Clove Leaf- CYP2C9, CYP3A4, CYP1A1 & CYP1B1 Inhibitor 

German Chamomile- CYP1A2 Inhibitor (Caffeine may also do this)



Also

GoldenSseal & Echinacea purpurea very effectively do the same thing. And people have reported using Vitamin B9 or Almond extract or Star Anise Extract and Tangerine Peels or Extract.

The 4 Oils listed are "AllylBenzenes", here is a larger list, but I am not sure if anyone has ever tried to Oilahuasca these yet, and I do not know if it is safe, so I am not suggesting anyone try these, they are just here for the sake of discussing them so people in the future can be safe.



Anethole, Apiol, Asarone, Carpacin, Chavibetol, Chavicol, Dillapiole, Eugenol, Isoeugenol, Isosafrole, Methyl Eugenol, Methyl Isoeugenol,

Here are the things that you need to make sure the Oil works.



Star Anise Extract or B9 for CYP2C9 Induction



Most important things:

CYP2C9 Induction

Alcohol Dehydrogenase Induction

Aldehyde Dehydrogenase Inhibition

Piperidine and or Dimethylamine Supplementation

Methyl from foods

Exercise or compounds that produce effects like exercise



Less important, but still factors:

SSAO Inhibition (Caffeine, Phenethylamine, Phenelalamine, Tryptamine)

MAO-A Induction

MAO-B Induction

NDMA Antagonism

Prolactin Inhibition


Hungarian Parsley Seed is a better source of Myristicin, just found that out. And the effects of it when activated properly are said to be like Mescaline and MDMA together. The P450 Enzymes CYP1A2 & CYP3A4 are what break this down and need to be inhibited. CYP2D6 could also play a big role.

Elmicin is something you either needs Chromotography type knowledge to get, or you have to buy it in small quantities. When activated properly it is like Mescaline, when activated wrong it is like Melatonin (sleepy). CYP1A1, CYP1B1, CYP1A2, CYP2A6, CYP2C9, CYP2A6, CYP2C9 & CYP2E1 are what are needed to be inhibited to activate this. CYP2D6 could also play an important role.

Safrole is like MDMA when activated properly and like Melatonin when not. CYP2A6, CYP2C9, and CYP2E1 are most important for this. CYP2D6 could also be important.

Methyl Chavicol when activated properly is like a light speedy LSD, when activated wrong it is said to be almost like Marijuana. CYP1A2 and CYP2A6 inhibit it, and CYP2D6 could also be important.

If the CYP2D6 Enzyme is inhibited with all the others, these are possibly visually hallucinogenic Oilahuascas. And the Methyl Chavicol doesn't build a tolerance (the others do) it actually gets stronger for you every time you use it, or you can use less. 


Dill seed extract also is said to be able to be used. As one of the main things, like in place of the Chavicol.

And apparently you can turn the main ingredients into 3 different forms, depending what you take:
Dimethylamine, Piperidine and the Pyrrolidine derivatives
Piperidine is said to be the strongest and is made by having Pepper or a Pepper replacement in your system.

And Apparently Elami oil can be activated by Valerian Root of Chinese origin, Coffee, Almond Extract & Glycerin (the stuff E-Cig liquid is made of), and nothing else. And it is like Mescaline. Someone told that guy that he didn't even need the Valerian root, and if he had added Vanilla or Cumin oil to his coffee, it could have been even stronger. So basically if someone were to drink a Nutmeg, Vanilla, Almond Coffee... They could trip and not even expect it. 


Valerian Root, B9, Anise seed are all interchangeable or to be used together
or replaced with:
DHEA (dehydroepiandrosterone)
Eugenol (inhibits/induces CYP2C9)
Ginkgo biloba (inhibits/induces CYP2C9)
Licorice (inhibits/induces CYP2C9)
Milk Thistle
Resveratrol (inhibits CYP2C9)
Saint John’s Wort (inhibits/induces CYP2C9)
Turmeric (inhibits/induces CYP2C9)

Pepper tea, with the solids taken out, seems to be the best thing for creating the base base.

L-Lysine is said to really help the pepper.

Vanilla and Cinnamon seem to be interchangable. They are both Aldehydes. 

German Chamomile does the best at blocking CYP1A2, but you can use Cayenne Peppers or Tangeretin. 

CYP2A6 can be inhibited by:
Almond Extract, Anise oil, Benzaldehyde, Cinnamaldehyde, Lemon oil, Lime oil, Orange oil, Limonene, Tangerine oil, Lemongrass oil, Nicotine

CYP2D6 Inhibition could mean the difference between Psychedelic effects and no effects. Here are the things that inhibit it:
CBD (Cannabidiol from Cannabis), Echinacea Purpurea, Pomegranate, Pummelo, Calamus oil, Kava, Black Cohosh

CYP3A4 is important to inhibit, which can be done with:
Catechin, Clove oil, Dill seed oil, Ginger, Goldenseal, Pomegranate, Cinnamon & Kava.

Kudzu seems to help protect it after it is formed. This can be replaced by Gallic Acid, Soy Isoflavones, Glycerin, Caffeine or Benzaldehydge.

And if anyone were to try these things with Mescaline or MDMA or DMT, they would probably get some awesome effects. I am not sure if anyone has tried it yet, but there may be other versions of Ayahuasca to make, where you take DMT orally and have it made into something else by inhibiting certain enzymes.

Cayenne Peppers promote Endophines and Adrenaline, so they also put things in the body that are helpful. 


From what I read earlier, any NMDA antagonist would be beneficial, but not crucial in the mix. This makes sense to me, because NMDA antagonists are things like, Ecstasy or Cough Medicine (Delsym) or MXE. So it would make sense that having something that has these effects would kind of kick the whole thing into a full blown experience.

So, Dextromotphan, that is what is in Cough Syrup and it is legal to buy, posses, etc. It is not any kind of drug. MXE is legal to buy and posses, but you are not allowed to take it unless you are a member of the Church of NeuroScience.

There are also plants that have these effects:
Uncaria Rhynchophyllia
Psychotria Colorata
Huperzia Serrata

Then there is the addition option of Prolactin Inhibition, which can be done with: 
Zinc, Ginko Vitamin E, B6, Almonds or Almond Extract & Magnesium
And possibly by anything that releases Dopamine or acts like it. So L-DOPA, THC, and a few other things maybe. 

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